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Ketua Tim Rocket, Giovanni, telah menemukan Mewtwo di daerah terpencil di wilayah Johto. Saat Giovanni mencoba untuk menangkap kembali Mewtwo, Ash dan teman-temannya diculik oleh Domino, anggota Tim Rocket baru, saat mencoba menyelamatkan Pikachu dari Jessie dan James. Pokemon klon juga ditangkap dan kemudian digunakan sebagai umpan untuk Mewtwo. Situasi kemudian menjadi pertempuran antara kehendak Mewtwo dan Giovanni; dan Mewtwo juga mencoba untuk menemukan apakah ia dan klon memiliki tujuan dalam hidup, meskipun mereka adalah produk sains.
Satoshi "Ash Ketchum"
Main
Pikachu
Main
Takeshi "Brock"
Main
Kasumi "Misty, World-class Beauty, Ondine"
Main
Mewtwo
Main
Domino "009, Black Tulip"
Main
Kojirou "James"
Supporting
Musashi "Jessie, Jessica, Princess Number 28"
Supporting
Nyarth "Meowth, Nyaasu"
Supporting
Mew
Supporting
Fushigidane "Bulbasaur"
Supporting
Togepi
Supporting
Koduck "Psyduck"
Supporting
Lizardon "Charizard"
Supporting
Sakaki "Giovanni"
Supporting
Soonansu "Wobbuffet"
Supporting
Zenigame "Squirtle"
Supporting
Joy "Nurse Joy"
Supporting
Chikorita
Supporting
Junsa "Officer Jenny"
Supporting
Narrator
Supporting
Doctor "Dr. Fuji" Fuji
Supporting
Kamex "Blastoise"
Supporting
Jugon "Dewgong"
Supporting
Rokon "Vulpix"
Supporting
Iwark "Onix"
Supporting
Butterfree
Supporting
Ishitsubute "Geodude"
Supporting
Nyorozo "Poliwhirl"
Supporting
Fushigibana "Venusaur"
Supporting
Pukurin "Wigglytuff"
Supporting
Gyarados
Supporting
Strike "Scyther"
Supporting
Luka Carson
Supporting
Nidoqueen
Supporting
Hitodeman "Staryu"
Supporting
Penicillina "Cullen Calix"
Supporting
Luna Carson
Supporting
Golduck
Supporting
Tajiri, Satoshi
Original Creator
Tajiri, Satoshi
Original Creator
Mima, Masafumi
Sound Director
Mima, Masafumi
Sound Director
Sugimori, Ken
Original Character Design
Sugimori, Ken
Original Character Design
Shudou, Takeshi
Script
Shudou, Takeshi
Script
Yuyama, Kunihiko
Director
Yuyama, Kunihiko
Director
Iwane, Masaaki
Key Animation, Animation Director
Iwane, Masaaki
Key Animation, Animation Director
Chiba, Yuriko
Key Animation
Chiba, Yuriko
Key Animation
Hidaka, Masamitsu
Director
Hidaka, Masamitsu
Director
Haigney, Michael
Producer, Script, ADR Director
Haigney, Michael
Producer, Script, ADR Director
Kanemura, Katsuyoshi
Art Director
Kanemura, Katsuyoshi
Art Director
Nicodème, Daniel
ADR Director
Nicodème, Daniel
ADR Director
Asada, Yuuji
Episode Director, Storyboard
Asada, Yuuji
Episode Director, Storyboard
